Sex chromosome nondisjunction

It gives rise to gametes with a chromosomal content that is different from the norm. Nondisjunction Nondisjunction is the failure of two members of a homologous pair of chromosomes to separate during meiosis. It is only required for male development.

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It gives rise to gametes with a chromosomal content that is different from the norm.

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A normal human possesses twenty-two pairs of autosomes and two sex chromosomes XY in the case of males and XX in the case of females. Down syndrome is an example of an autosomal trisomy as it involves one of the autosomes "autosome" is the term that designates all the chromosomes other than the X and Y, or sex, chromosomes. Fatal versus Nonfatal Conditions In order to understand why some aneuploid conditions are fatal and others such as those mentioned above are not, one must understand the concept of gene dosage and its importance in development. Retrieved January 16, from Encyclopedia. Similarly, XYY males have relatively few clinical symptoms and appear phenotypically normal.
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  1. Molecular Biology of the Cell, 3rd ed. Although the X chromosome is very large, only one is used in development in every femalecell one of the two X chromosomes is inactivated at random.